{"id":7394,"date":"2024-01-24T09:43:58","date_gmt":"2024-01-24T12:43:58","guid":{"rendered":"https:\/\/biomedicos.fi.mdp.edu.ar\/?p=7394"},"modified":"2024-01-24T09:43:58","modified_gmt":"2024-01-24T12:43:58","slug":"biomaterials-science","status":"publish","type":"post","link":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/biomaterials-science\/","title":{"rendered":"Biomaterials Science"},"content":{"rendered":"<p><strong>Cover of Biomaterials Science:<\/strong><\/p>\n<p>A. Sonzogni, G. Rivero, V. Gonz\u00e1lez, G.A. Abraham, M. Calder\u00f3n, R. Minari.\u00a0<strong>Nano-in-nano enteric protein delivery system: coaxial Eudragit\u00ae L100-55 fibers containing poly(N-vinylcaprolactam) nanogels<\/strong>. Biomaterials Science, 12, 335, 2024. ISSN: 2047-4849.<br \/>\ndoi.org\/10.1039\/d3bm01422c<\/p>\n<p><strong>Abstract<\/strong><br \/>\nOral protein delivery holds significant promise as an effective therapeutic strategy for treating a wide<br \/>\nrange of diseases. However, effective absorption of proteins faces challenges due to biological barriers<br \/>\nsuch as harsh conditions of the stomach and the low permeability of mucous membranes. To address<br \/>\nthese challenges, this article presents a novel nano-in-nano platform designed for enteric protein delivery.<br \/>\nThis platform, obtained by electrospinning, involves a coaxial arrangement comprising poly(N-vinylcaprolactam)<br \/>\nnanogels (NGs) enclosed within nanofibers of Eudragit\u00ae L100-55 (EU), a pH-responsive polymer.<br \/>\nThe pH-selective solubility of EU ensures the protection of NGs during their passage through the<br \/>\nstomach, where the fibers remain intact at low pH, and releases them in the intestine where EU dissolves.<br \/>\nThe switchable characteristic of this nano-in-nano platform is confirmed by using NGs loaded with a<br \/>\nmodel protein (ovalbumin), which is selectively released when the intestinal pH is achieved. The versatility<br \/>\nof this nano-in-nano delivery platform is demonstrated by the ability to modify the fibers dissolution<br \/>\nprofile simply by adjusting the concentration of EU used in the electrospinning process. Furthermore, by<br \/>\ntuning the properties of NGs, the potential applications of this platform can be further extended, paving<br \/>\nthe way for diverse therapeutic possibilities<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cover of Biomaterials Science: A. Sonzogni, G. Rivero, V. Gonz\u00e1lez, G.A. Abraham, M. Calder\u00f3n, R. Minari.\u00a0Nano-in-nano enteric protein delivery system: coaxial Eudragit\u00ae L100-55 fibers containing poly(N-vinylcaprolactam) nanogels. Biomaterials Science, 12, 335, 2024. ISSN: 2047-4849. doi.org\/10.1039\/d3bm01422c Abstract Oral protein delivery holds significant promise as an effective therapeutic strategy for treating a wide range of diseases. However, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7392,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108,102],"tags":[],"class_list":["post-7394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-destacada-en-2","category-destacada-en"],"featured_image_src":{"landsacpe":["https:\/\/biomedicos.fi.mdp.edu.ar\/wp-content\/uploads\/2024\/01\/TAPA.png",593,445,false],"list":["https:\/\/biomedicos.fi.mdp.edu.ar\/wp-content\/uploads\/2024\/01\/TAPA-463x348.png",463,348,true],"medium":["https:\/\/biomedicos.fi.mdp.edu.ar\/wp-content\/uploads\/2024\/01\/TAPA.png",1000,750,false],"full":["https:\/\/biomedicos.fi.mdp.edu.ar\/wp-content\/uploads\/2024\/01\/TAPA.png",1000,750,false]},"_links":{"self":[{"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/posts\/7394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/comments?post=7394"}],"version-history":[{"count":0,"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/posts\/7394\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/media\/7392"}],"wp:attachment":[{"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/media?parent=7394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/categories?post=7394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomedicos.fi.mdp.edu.ar\/en\/wp-json\/wp\/v2\/tags?post=7394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}